After tech helped the Medicines and Healthcare products Regulatory Agency play a starring role in government’s coronavirus response, digital chief Claire Harrison tells PublicTechnology where the watchdog’s story went next
During its 21 years in existence – and notwithstanding all its incredibly important work during that time – the Medicines and Healthcare products Regulatory Agency has rarely been among the most high-profile parts of government.
That all changed during the latter half of 2020.
By 2 December, the MHRA was ready to issue its first approval for a Covid-19 vaccine and, within a week of that, the first jab had been administered and the UK had become the first country in the world to start a mass programme of immunisation.
The efforts of the medical regulator were a crucial part of the delivery of a vaccine rollout that was widely praised for its effectiveness and expeditiousness. But the initiative also brought more negative attention.
In July 2020, ministers and security authorities accused accused Kremlin-backed cybercriminals of launching “despicable” attacks on various organisations involved in the development and delivery of vaccines.
It seems they were far from the only ones.
Claire Harrison, chief digital and technology officer at the MHRA, tells PublicTechnology that “around the time of the vaccine rollout, MHRA was regularly in the top five or even top three targets” in the country for cyberattackers.
Even in an ordinary month, the organisation – like many government agencies – frequently attracts the attention of hostile actors, facing an average of 25,000 cyber alerts.
It is not surprise then that cyber is one of three “strategic themes” running through the watchdog’s digital and technology work. It sits alongside tackling legacy tech and pursuing innovation and, according to Harrison, the three areas work symbiotically.
“You can have all the AI and cutting-edge technology you want – and we’re doing lots of great work in that space – but cyber then needs to not only keep up with it, but needs to be in front of emerging tech to be able to protect the organisation,” she says.
“AI is not going to make anyone redundant, but it could help staff by enabling them to focus on the really difficult cases that are extremely complex and do require a lot more human intervention”
To this end – and with hostile actors deploying automation to industrialise their attacks – the MHRA is experimenting with using AI to help stay one step ahead.
The regulator is currently engaged in exploring about 20 use cases for AI technology, around one in three of which relate to boosting cyber defences.
“It’s around identifying threats really, really quickly, and finding our vulnerabilities really quickly as well, because we’re trying to counteract the way that AI is used [against] us,” Harrison says.
Risks and rewards
Across all of the MHRA’s investigations of AI, the digital chief says there is a “spectrum of risk” for potential use cases, broadly split into three categories: productivity; decision-support; and decision-making.
The first of these is comprised largely of generic uses that could be applied to the back-office functions and other processes of any organisations, in any sector,
At the opposite end of the spectrum, autonomous decision-making use cases currently represent the “the scary stuff” that the vast majority of organisations – and not just those in the necessarily risk-averse world of regulators – would currently steer clear of, according to Harrison.
“But in the middle we have decision support,” she adds. “That is about teaching machines to make decisions and using different types of AI and other technologies to enable that – but all the time, or at regular points, there’s human interaction. And then the human makes the final decision – but based on the evidence that’s been gathered and assimilated with the help of AI.”
An example of such a potential use case currently being explored would be in the MHRA’s enforcement operations to crack down on counterfeit medicines or products, where automated technology could help detect those operating cross the vast online marketplace.
Harrison (pictured below right) says: “We work with the National Crime Agency and local authorities, but we’re forever trying to find and then shut down dodgy websites – that’s quite an arduous task, especially manually, when it’s just humans who are looking and reporting and dealing with it.”
Another possible deployment under examination is in the watchdog’s work to assess the approximately 1,000 applications that annual statistics indicate it receives in a typical year to conduct clinical trials for new medical products.
The MHRA is exploring how AI could be used to scour historic applications and detect common factors in those that were not approved – known as a grounds for non-acceptance (GNA) decision. This intelligence could then be provided onto assessors to support their decision – particularly in cases where there is a clear and simple reason to issue a GNA ruling.
“A human would decide, ultimately, but a lot of the work that’s been done to that point [can be performed by] machines,” Harrison says. “The benefits there are not only the time it saves, but the consistency as well.”
She adds: “It’s not going to make anyone redundant, but it could help staff by enabling them to focus on the really difficult cases that extremely complex and do require a lot more human intervention.”
Legacy and learning
The other of the regulator’s three key digital themes – tackling legacy – goes beyond ripping out and replacing the systems, according to the digital and technology leader.
“Whenever we’ve got legacy tech, legacy ways of working, legacy commercial agreements, all of those are blockers,” she says. “It’s a continuous programme, because what we need to do as well is make sure that we’re not creating the legacy tech of the future. So, we are really careful with our tech strategies and our tech selection and who selects our tech, but also the way that it’s maintained and the budget for it, and the interoperability aspects.”
2 December 2020
Date on which the MHRA approved the first Covid-19 vaccine for UK use – making it one of the first regulators in the world to do so
120
Size of MHRA’s digital, data and technology workforce – about one in 10 of the watchdog’s overall headcount
1,000
Approximate number of applications for clinical trials the organisation receives in a typical year, equating to about three every day that require assessment
To support all of its technology objectives, the MHRA – and Harrison herself – have focused in recent years on engaging with other government agencies, as well as counterparts overseas.
Among those with which the regulator has joined forces is Swissmedic – Switzerland’s equivalent to the MHRA. The two parties are engaged in a “continuous collaboration”, including a joint hackathon exercise taking place with regulators from around the globe a few days after PublicTechnology talks to Harrison, and in which “our teams will be sitting down together and coding together.”
The two organisations have made comparative progress in differing areas – for example Swissmedic is advanced in its use of AI to tackle counterfeit products, while the MHRA has made gains in using tech to help assess planned clinical trials – meaning it is “expediting learning for each of us”, according to Harrison.
The digital and tech chief sits at the head of a workforce of about 120 people – and she hopes to make the case to grow this figure.
Any new recruits will join a team led by someone whose career experience as a “really hands-on techie” continues to manifest both in her professional life and beyond.
She says: “I still love technology and I still do it in my spare time for my friends – I fix their laptops and I create websites for them, for example: I start with a blank notepad and type all my coding – I’m old school: I don’t use WordPress or anything! I continue to be fascinated by the art of the possible – which can be terrifying, but exhilarating as well. It’s still massively interesting, and it’s still the place to be.”
Для естественной вентиляции необходимы вентиляционные канал и решетка. Вентиляционная решетка располагается на стене в кухне и в санузле. Через нее уходит отработанный воздух.
Регулярно протирайте решетки вентиляции. Делайте это влажной тряпкой не реже, чем раз в месяц.
3. Спальня
* **Разница давления:** Вентиляционные каналы, которые обычно располагаются в санузлах и кухнях, создают низкое давление, которое засасывает воздух из помещения.
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Недостаточная вентиляция – это как тихое, незаметное, РЅРѕ постоянное отравление. Р’ ежедневной жизни РјС‹ часто создаем условия для его возникновения, РЅРµ задумываясь Рѕ последствиях. Р’ непродуманных помещениях РјС‹ запираем вредные вещества РІ “”ловушку””, Рё РѕРЅРё стают тихим убийцей нашего Р·РґРѕСЂРѕРІСЊСЏ.
4. Установка вентиляционных решеток и заглушек
Какие помещения защищаются системами противодымной вентиляции?
Разработка схемы вентиляции. Создается чертеж системы, на котором указаны все элементы вентиляции, их расположение, типы воздуховодов и другие важные детали.
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4. Проверка работы вентиляции
Школы и детские сады
3. Утепление каналов
Вентиляционная система в монолитном доме обычно состоит из следующих элементов:
Тип вентиляции. Чистка общедомовой вентиляции стоит дороже, чем чистка локальной вентиляции в ванной или на кухне.
* **Проверка тяги:** Специальным прибором измеряется скорость движения воздуха, чтобы определить, насколько эффективно система справляется со своими задачами.
В монолитных домах могут быть реализованы различные системы вентиляции, которые отличаются по принципу работы и эффективности:
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* **Неэффективность:** Система вентиляции может работать неэффективно, если она неправильно настроена или требует ремонта.
* V – объем помещения, РјВі
* **Качество отводимого воздуха**: отводимый воздух должен быть очищен от вредных веществ до максимально возможного уровня.
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* **Улучшает микроклимат.** Правильно установленная вентиляция обеспечивает постоянный приток свежего РІРѕР·РґСѓС…Р°, поддерживая комфортную температуру Рё влажность. Рто особенно важно РІ зимнее время, РєРѕРіРґР° РІРѕР·РґСѓС… РІ квартире может быть СЃСѓС…РёРј Рё холодным.
Канальная вентиляция использует сеть воздуховодов, по которым воздух подается в помещение. В качестве оборудования применяются вентиляционные установки, которые обеспечивают подачу, очистку, нагрев, охлаждение и увлажнение воздуха.
* **Проверьте ее плотную фиксацию.**
* **Ремонт вентиляционных систем**: в случае поломки, именно управляющая компания должна организовать ремонт или замену элементов системы.
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Мой опыт покупки автомобиля с АКПП в автосалоне
Долгожданный тест-драйв! Сразу скажу‚ что я никогда раньше не водил машину с автоматической коробкой передач. Всегда был приверженцем механики‚ считая‚ что она дает больше контроля над автомобилем. Однако‚ в этот раз решил попробовать что-то новое. Менеджер автосалона любезно предложил мне прокатиться на выбранном Nissan Qashqai. Первые несколько минут я чувствовал себя немного неуверенно. Переключение передач происходило плавно‚ без рывков‚ что было непривычно после резких переключений на механике. Мне показалось‚ что динамика разгона немного снизилась‚ но это‚ возможно‚ субъективное ощущение. На самом деле‚ я быстро привык к плавному переключению вариатора. Он мягко реагировал на нажатие педали газа‚ без резких толчков. Это было очень комфортно‚ особенно в городском потоке.
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Во-вторых, автоматическая система работает независимо от условий освещенности. Даже в пасмурную погоду, когда видимость кажется достаточной, фары значительно повышают заметность автомобиля. Это особенно актуально в условиях города, где интенсивность движения и наличие препятствий требуют максимальной концентрации и видимости. Система не требует от водителя принятия решения о необходимости включения фар, она делает это автоматически, освобождая водителя от лишних действий и повышая его концентрацию на дороге.
После согласования всех условий‚ мы перешли к оформлению документов. Этот процесс занял довольно много времени‚ около двух часов. Мне пришлось заполнить множество бланков‚ предоставить необходимые документы? паспорт‚ водительское удостоверение‚ ИНН; Менеджер терпеливо объяснял каждый пункт договора‚ отвечал на все мои вопросы. Я внимательно изучил все документы‚ перед тем как поставить свою подпись. Никакого давления со стороны менеджера не было‚ что очень важно. Наконец‚ все формальности были завершены. Мне выдали ключи от моего нового автомобиля‚ страховой полис и необходимые документы на машину. Получив все документы‚ я провел предпродажную подготовку машины — проверил комплектацию‚ посмотрел на наличие всех элементов‚ указанных в договоре. Все соответствовало действительности. Я оплатил стоимость автомобиля безналичным расчетом‚ что было очень удобно.
Преимущества автоматического включения фар
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Хочу рассказать, как я избавился от папиллом при помощи лазера.
Я долго сомневался, стоит ли идти на лазерное удаление, но в итоге решился.
Само удаление заняло буквально несколько минут.
Удаление лазером — это немного неприятно, но гораздо лучше, чем я думал.
Ожидал, что останется хоть какой-то след, но ничего не осталось.
Прошло около месяца, и никаких новых папиллом не возникло.
Сначала изучал разные методы — удаление азотом, химией, но остановился на лазере и не пожалел.
Есть ли здесь те, кто удалял папилломы лазером? Как долго у вас не возвращались папилломы?
Может, кто-то знает, что помогает быстрее восстановить кожу после удаления папиллом?
Спасибо за ваши ответы и помощь!
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Система автоматического включения фар при запуске двигателя основывается на взаимодействии нескольких компонентов. Главный элемент – это электронный блок управления (ЭБУ), который обрабатывает сигналы от различных датчиков и управляет работой освещения. Включение фар происходит автоматически после запуска двигателя, сигнал о котором поступает от системы зажигания. Дополнительные датчики, например, датчики света, могут корректировать работу системы в зависимости от уровня освещенности.
Наконец, некоторые водители могут испытывать дискомфорт от автоматического включения фар, предпочитая самостоятельно управлять освещением. Это связано с субъективными предпочтениями и привычками вождения. Несмотря на то, что система автоматического включения фар разработана для повышения безопасности и комфорта, она не может полностью удовлетворить всех водителей.
Процесс покупки? от выбора до оформления документов
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Также следует отметить, что система автоматического включения фар не заменяет собой необходимость внимательности и ответственности водителя. Водитель должен всегда контролировать освещение автомобиля и в случае необходимости корректировать его работу вручную. Например, в условиях сильного тумана или снегопада, автоматическая система может не обеспечить достаточный уровень освещения, и водителю потребуется самостоятельно переключиться на более мощные фары или включить противотуманные огни.
Долгожданный тест-драйв! Сразу скажу‚ что я никогда раньше не водил машину с автоматической коробкой передач. Всегда был приверженцем механики‚ считая‚ что она дает больше контроля над автомобилем. Однако‚ в этот раз решил попробовать что-то новое. Менеджер автосалона любезно предложил мне прокатиться на выбранном Nissan Qashqai. Первые несколько минут я чувствовал себя немного неуверенно. Переключение передач происходило плавно‚ без рывков‚ что было непривычно после резких переключений на механике. Мне показалось‚ что динамика разгона немного снизилась‚ но это‚ возможно‚ субъективное ощущение. На самом деле‚ я быстро привык к плавному переключению вариатора. Он мягко реагировал на нажатие педали газа‚ без резких толчков. Это было очень комфортно‚ особенно в городском потоке.
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My kitchen renovation started with a daunting taskтБЪ finding the perfect free online design tool. I initially felt overwhelmed by the sheer number of options available. I spent several days researchingтАЪ reading reviewsтАЪ and comparing features. Some platforms boasted impressive 3D rendering capabilitiesтАЪ but lacked the intuitive interface I craved. Others offered simpler designs but lacked customization options. I needed a balance of visual appeal and user-friendliness. After much deliberationтАЪ I settled on “KitchenCraft ProтАЪ” a platform recommended by a friendтАЪ Amelia. KitchenCraft Pro offered a user-friendly drag-and-drop interfaceтАЪ a wide selection of appliances and cabinetry stylesтАЪ and surprisingly detailed customization options. The initial learning curve was minimal; I was able to navigate the software and start designing within minutes. I particularly appreciated the ability to import my own images and textures to personalize the designтАЪ ensuring it accurately reflected my unique style and preferences. The free version provided ample features for my needsтАЪ although I did note that some advanced featuresтАЪ like photorealistic renderingтАЪ were reserved for paid subscriptions. HoweverтАЪ for my purposesтАЪ the free tools were more than sufficient. The decision to use KitchenCraft Pro proved to be a great oneтАЪ setting the stage for a successful and enjoyable design process. I highly recommend thoroughly researching and comparing different free online kitchen design tools before making your choiceтАЪ to ensure you find one that best suits your specific needs and skill level. Remember to look for intuitive interfacesтАЪ a wide range of optionsтАЪ and helpful tutorials or support resources.
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With my chosen design toolтАЪ KitchenCraft ProтАЪ selectedтАЪ the next step was inputting my kitchen’s precise measurements. This proved surprisingly straightforward. The software guided me through a step-by-step processтАЪ prompting me to enter the length and width of each wallтАЪ the location of windows and doorsтАЪ and the dimensions of existing fixtures like sinks and ovens. I found the interface incredibly intuitiveтАЪ with clear instructions and helpful visual aids. I even appreciated the option to upload a floor plan image to assist with the process. InitiallyтАЪ I struggled a bit with accurately measuring some awkwardly shaped alcovesтАЪ but the platform’s customer support chat was incredibly helpfulтАЪ providing quick and efficient guidance. Once the dimensions were finalizedтАЪ I began to personalize the design. This is where the fun really started! I selected my preferred cabinet stylesтАЪ choosing from a comprehensive library of options ranging from sleek modern designs to more traditionalтАЪ rustic styles. I meticulously chose the colorsтАЪ finishesтАЪ and countertop materialsтАЪ experimenting with different combinations to find the perfect aesthetic. I even incorporated my existing appliancesтАЪ ensuring they fit seamlessly into the new layout. The software allowed for precise placement of every elementтАЪ down to the smallest detail. I spent hours tweaking and refiningтАЪ meticulously considering factors such as workflow efficiency and aesthetic harmony. The process felt like playing a sophisticated digital puzzleтАЪ and the satisfaction of seeing my vision slowly take shape on the screen was incredibly rewarding. I discovered that the software’s flexibility allowed me to explore different layouts and experiment with various design choices without any commitmentтАЪ a feature I truly appreciated. It was a crucial step in ensuring my final design would be both functional and visually appealing.
Refining the Design and Adding Details
My Free Online Kitchen Design Journey
Exporting and Sharing My Design
I embarked on a thrilling kitchen redesignтАЪ leveraging free online tools. My goal? A stunningтАЪ functional space without breaking the bank. I spent hours exploring various platformsтАЪ comparing features and ease of use. The process felt surprisingly intuitive. I was amazed by how quickly I could visualize different layouts and experiment with various appliances and cabinetry. It was a fun and empowering experienceтАЪ proving that achieving a dream kitchen doesn’t require a hefty budget!
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Before I even thought about buying shelves or hanging rodsтАЪ I knew I needed a proper planтАд Armed with a measuring tape and a notebookтАЪ I meticulously documented every inch of my tiny closetтАд I measured the widthтАЪ the depthтАЪ and the heightтАЪ noting any obstructions like pipes or electrical outletsтАд This detailed assessment was crucialтАд I also carefully inventoried my belongingsтАд I pulled everything out тАУ every shirtтАЪ every pair of pantsтАЪ every scarf and shoe тАУ and sorted it into categoriesтБЪ topsтАЪ bottomsтАЪ dressesтАЪ shoesтАЪ accessoriesтАЪ etcтАд This helped me visualize the amount of space I needed for each categoryтАд Then came the fun partтБЪ sketching! I drew several different layouts in my notebookтАЪ experimenting with different shelving configurations and hanging rod placementsтАд I considered the placement of my longer dresses and coatsтАЪ and how to best utilize the vertical spaceтАд I also thought about the flow of the closet тАУ how easily I could access different itemsтАд I even considered the type of storage solutions I might need тАУ baskets for smaller itemsтАЪ drawers for folded clothesтАЪ etcтАд InitiallyтАЪ I considered custom built-insтАЪ but the cost was prohibitiveтАд ThereforeтАЪ I opted for a more budget-friendly approachтАЪ focusing on maximizing the space with readily available shelving and storage solutionsтАд My planning phase took a few eveningsтАЪ but it was worth itтАд Having a clear plan before I started shopping prevented impulsive purchases and ensured I bought the right amount of storage to perfectly fit my spaceтАд It was surprisingly satisfying to see my ideas take shape on paperтАЪ and I felt a sense of accomplishment even before IтАЩd started the actual transformationтАд
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